2020 Computer-Aided Drug Design(Jinan University) 最新满分章节测试答案

本答案对应课程为:点我自动跳转查看
本课程起止时间为:2020-12-09到2021-02-28
本篇答案更新状态:已完结

Chapter one： The background of CADD Unit test 1

1、 问题:Which of the following diseases could be treated by the "Glenin" in the movie "Dying to survive" ?
选项：
A:Heart disease
B:Leukemia
C:Cerebrovascular disease
D:Cirrhosis
答案: 【Leukemia】

2、 问题:In addition to being able to speed up target discovery, what is the other advantage of CADD ?
选项：
A:Increase drug targets
B:Improve the inclusion of targets
C:Find more targets
D:Improve the accuracy of target discovery
答案: 【Improve the accuracy of target discovery】

3、 问题:What are the main problems of CADD at present ?
选项：
A:Authenticity and usability of three-dimensional protein structure
B:The way of receptor ligand interaction
C:Whether the designed molecule can be chemically synthesized
D:Drug transport, metabolism and side effects in vivo
答案: 【Authenticity and usability of three-dimensional protein structure;
The way of receptor ligand interaction;
Whether the designed molecule can be chemically synthesized;
Drug transport, metabolism and side effects in vivo】

4、 问题:Computer aided drug design uses pharmacophore models, quantum mechanics, molecular dynamics, the quantitative structure-activity relationship (QSAR), etc, on enzyme or receptor, so as to achieve the purpose of drug design.
选项：
A:正确
B:错误
答案: 【正确】

5、 问题:At present, a new drug can be designed automatically by computer.
选项：
A:正确
B:错误
答案: 【错误】

6、 问题:A lead compound in drug discovery is a chemical compound that has pharmacological or biological activity and whose chemical structure is used as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters.
选项：
A:正确
B:错误
答案: 【正确】

Chapter two： The past life of CADD Unit test 2

1、 问题:What are the targets of drug action ?
选项：
A:Recipient
B:ion channel
C:enzyme
D:Endogenous small molecular matter
答案: 【Recipient;
ion channel;
enzyme;
Endogenous small molecular matter】

2、 问题:Which of the following are endogenous ligands of receptors?
选项：
A:Neurotransmitter
B:hormone
C:Autoactive substance
D:Mycoplasma
答案: 【Neurotransmitter;
hormone;
Autoactive substance】

3、 问题:What are the characteristics of receptors ?
选项：
A:Specificity
B:High affinity
C:Saturability
D:Reversibility
答案: 【Specificity;
High affinity;
Saturability;
Reversibility】

4、 问题:The specificity of drug action depends on the specificity of drug molecule binding to its receptor.
选项：
A:正确
B:错误
答案: 【正确】

5、 问题:Modern drug discovery also has its limitations. Its research object is "drug-disease" relationship rather than "target-drug" relationship.
选项：
A:正确
B:错误
答案: 【错误】

6、 问题:The substances that can specifically bind to the receptors in the body are called ligands.
选项：
A:正确
B:错误
答案: 【正确】

7、 问题:The receptor is the biomacromolecule that can interact with drugs and initiate cell reaction.
选项：
A:正确
B:错误
答案: 【正确】

Chapter three： The present life of CADD Unit test 3

1、 问题:What is the most common method used to build QSAR model ?
选项：
A:Simplex algorithm
B:Partial least square method
C:least square method